COLLAGEN PEPTIDES

Summary

Collagen peptides (hydrolyzed collagen) are orally administered, bioactive peptide fragments studied as a dietary supplement for skin and joint health. A double-blind, placebo-controlled trial found that daily oral collagen peptides significantly improved skin elasticity versus placebo, with a positive influence on skin moisture and evaporation ^[1]. In active adults, a randomized controlled trial reported that 10-20 g/day over 6-9 months improved activities of daily living, pain, and physical and mental quality-of-life measures ^[2]. A systematic review concluded collagen supplementation is most beneficial for improving joint functionality and reducing joint pain, with some effects on body composition and recovery, while noting mechanisms remain unclear and call for larger studies ^[4]; hydrolyzed collagen is thought to deliver biologically active peptides that reach joint tissues ^[3]. Evidence is supported by numerous human RCTs, though it is a supplement rather than an FDA-approved drug.

Sources

1. 1. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study Skin pharmacology and physiology, 2014.
2. 2. Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults Journal of the International Society of Sports Nutrition, 2023.
3. 3. Collagen Supplementation for Joint Health: The Link between Composition and Scientific Knowledge Nutrients, 2023.
4. 4. The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review Amino acids, 2021.

For educational purposes only.