DEMOXYTOCIN

Summary

Demoxytocin is an oxytocin analog administered buccally (as resoriblets or tablets) and historically studied for induction and stimulation of labor. Older randomized and comparative trials compared buccal demoxytocin with oral prostaglandin E2: delivery and labor-induction success rates were broadly similar between agents, with no significant difference in fetal distress, instrumental delivery, or low Apgar scores ^[1,3,4]. Across these studies, demoxytocin consistently produced fewer gastrointestinal side effects (vomiting, diarrhea) than PGE2 ^[2,3], though its efficacy was not superior and one study noted intravenous oxytocin remained clearly better ^[2]. The evidence is moderate but dated, drawn from small obstetric trials from the late 1970s-1980s, with no modern RCTs, meta-analyses, or FDA record provided.

Sources

1. 1. Induction of labor with oral prostaglandin E2 and buccal demoxytocin without amniotomy Acta obstetricia et gynecologica Scandinavica, 1981.
2. 2. Use of oral oxytocics for stimulation of labor in cases of premature rupture of the membranes at term. A randomized comparative study of prostaglandin E2 tablets and demoxytocin resoriblets Acta obstetricia et gynecologica Scandinavica, 1983.
3. 3. Oral oxytocics for induction of labor. A randomized study of prostaglandin E2 tablets and demoxytocin resoriblets Acta obstetricia et gynecologica Scandinavica, 1983.
4. 4. A comparative study of labor induced by oral prostaglandin E2 and buccal tablets of demoxytocin International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1979.

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