GONADORELIN

Summary

Gonadorelin is synthetic luteinizing hormone-releasing hormone (LH-RH/GnRH), a long-established neuropeptide used therapeutically and as a diagnostic agent, and now also flagged as a substance misused in sports doping ^[2,4]. Acting on pituitary GnRH receptors, it governs release of LH and FSH; the broader GnRH-analog class is clinically validated, exemplified by the GnRH antagonist ganirelix, which in a large multicentre IVF trial effectively suppressed LH surges during controlled ovarian stimulation and achieved a vital pregnancy rate of 40.3% per embryo transfer ^[1]. Gonadorelin itself has decades of documented clinical use as synthetic LH-RH ^[4]. The provided abstracts are largely descriptive or analytical rather than fresh efficacy trials of gonadorelin per se, but its identity as an approved hormonal therapeutic with extensive clinical history supports a strong evidence grade ^[1,4].

Sources

1. 1. Ganirelix Drugs, 2000.
2. 2. Advances and perspectives in the analytical technology for small peptide hormones analysis: A glimpse to gonadorelin Journal of pharmaceutical and biomedical analysis, 2023.
3. 4. Gonadorelin--synthetic LH-RH The Medical letter on drugs and therapeutics, 1983.

For educational purposes only.