VILON

Summary

Vilon (Lys-Glu) is a short synthetic dipeptide bioregulator studied primarily for anti-aging and gene-regulatory effects, but the provided evidence is almost entirely preclinical. In cultured lymphocytes from elderly donors, Vilon induced deheterochromatinization and reactivation of ribosomal genes ^[2], and DNA-microarray studies in mouse heart showed it altered expression of a subset of genes, alone or combined with Epithalon ^[3]. In aged rats, orally administered Vilon improved small-intestinal glucose and glycine transport characteristics ^[4]. None of the provided papers report human interventional randomized controlled trials of administering Vilon as a therapeutic, and one cited item is an unrelated bioinformatics network method that merely shares the acronym "ViLoN" ^[1]. The clinical evidence base in these sources is therefore minimal and the findings should be considered preliminary.

Sources

1. 1. ViLoN-a multi-layer network approach to data integration demonstrated for patient stratification Nucleic acids research, 2023.
2. 2. Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people Biogerontology, 2004.
3. 3. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology Bulletin of experimental biology and medicine, 2002.
4. 4. Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats Bulletin of experimental biology and medicine, 2002.

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